Myeloproliferative Neoplasms in Patients below 25 Years Old at Diagnosis: A Retrospective International Cooperative Work
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چکیده
منابع مشابه
Multicenter Retrospective Analysis of Turkish Patients with Chronic Myeloproliferative Neoplasms
OBJECTIVE Chronic myeloproliferative neoplasms (CMPNs) that include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are Philadelphia-negative malignancies characterized by a clonal proliferation of one or several lineages. The aim of this report was to determine the demographic features, disease characteristics, treatment strategies, and survival rates of...
متن کاملAssociation of JAK2 mutation status and cytogenetic abnormalities at diagnosis in myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms.
1. Laposata M. Teaching laboratory management to pathology residents: what skill set are we trying to impart? Am J Clin Pathol. 2012;137:16-18. 2. Wagar EA, Horowitz RE, Siegal GP, eds. Laboratory Administration for Pathologists. Northfield, IL: CAP Press; 2011. its wiki format, it can become a backbone on which many in the pathology and laboratory medicine community can “hang” useful training ...
متن کاملMyeloproliferative neoplasms in five multiple sclerosis patients☆
The concurrence of myeloproliferative neoplasms (MPNs) and multiple sclerosis (MS) is unusual. We report five patients from a localized geographic area in Denmark with both MS and MPN; all the patients were diagnosed with MPNs in the years 2007-2012. We describe the patients' history and treatment. A potential link between MS and MPNs has not been previously recognized. This observation calls a...
متن کاملEpigenetics in Myeloproliferative Neoplasms
A decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence but are reversible modifications that dictate the ...
متن کاملRecent advances in diagnosis and treatment of chronic myeloproliferative neoplasms
The Philadelphia chromosome-negative chronic myeloproliferative neoplasms (MPNs) have recently been the focus of tremendous advances in basic knowledge of disease pathophysiology following the recognition of mutations in JAK2 and MPL. These discoveries also led to refinement of the criteria employed for diagnosis. The prognostic roles of the JAK2 V617F mutation and of leukocytosis as independen...
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ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-112374